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Click-to-lead design of a picomolar ABA receptor antagonist with potent activity in vivo.

• Authors : Vaidya, Aditya S.^1,2; Peterson, Francis C.³; Eckhardt, James^1,2

Subjects: *ABSCISIC acid; *CLICK chemistry; *PLANT hormones

• Source: Proceedings of the National Academy of Sciences of the United States of America. 9/21/2021, Vol. 118 Issue 38, p1-7. 7p.

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Identification of simple arylfluorosulfates as potent agents against resistant bacteria.

• Authors : Jiong Zhang¹; Xiangxiang Zhao²; Cappiello, John R.³

Subjects: *CLICK chemistry; *ANTIBACTERIAL agents; *MULTIDRUG resistance

• Source: Proceedings of the National Academy of Sciences of the United States of America. 7/13/2021, Vol. 118 Issue 28, p1-7. 7p.

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SuFEx-enabled, agnostic discovery of covalent inhibitors of human neutrophil elastase.

• Authors : Qinheng Zheng¹; Woehl, Jordan L.²; Kitamura, Seiya²

Subjects: *LEUCOCYTE elastase; *CLICK chemistry; *BIOLOGICAL assay

• Source: Proceedings of the National Academy of Sciences of the United States of America. 9/17/2019, Vol. 116 Issue 38, p18808-18814. 7p.

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A real-time, click chemistry imaging approach reveals stimulus-specific subcellular locations of phospholipase D activity.

• Authors : Dongjun Liang^1,2; Kane Wu^1,2; Reika Tei^1,2

Subjects: *PHOSPHOLIPASE D; *CLICK chemistry; *G protein coupled receptors

• Source: Proceedings of the National Academy of Sciences of the United States of America. 7/30/2019, Vol. 116 Issue 31, p15453-15462. 10p.

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Use of NAD tagSeq II to identify growth phase-dependent alterations in E. coli RNA NAD+ capping.

• Authors : Hailei Zhang; Huan Zhong; Xufeng Wang

Subjects: RNA; GENETIC regulation; CLICK chemistry

• Source: Proceedings of the National Academy of Sciences of the United States of America; 4/6/2021, Vol. 118 Issue 14, p1-11, 11p

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Semisynthetic protein nanoreactor for single-molecule chemistry.

• Authors : Joongoo Lee¹; Bayley, Hagan¹

Subjects: *SINGLE molecules; *CLICK chemistry; *ALKYNES

• Source: Proceedings of the National Academy of Sciences of the United States of America. 11/10/2015, Vol. 112 Issue 45, p13768-13773. 6p.

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Shapeshifting bullvalene-linked vancomycin dimers as effective antibiotics against multidrug-resistant gram-positive bacteria

• Authors : Ottonello, Alessandra; Wyllie, Jessica A.; Robinson, Carol V. ...

Subjects: click chemistry; shapeshifting antibiotics; resistant bacterial infections

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Snapshots of a modified nucleotide moving through the confines of a DNA polymerase.

• Authors : Kropp, Heike Maria; Dürr, Simon Leonard; Peter, Christine

Subjects: DNA polymerases; NUCLEOTIDES; PHOTOGRAPHS

• Source: Proceedings of the National Academy of Sciences of the United States of America; 10/2/2018, Vol. 115 Issue 40, p9992-9997, 6p

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Observation of the controlled assembly of preclick components in the in situ click chemistry generation of a chitinase inhibitor.

• Authors : Hirose, Tomoyasu¹; Maita, Nobuo²; Gouda, Hiroaki³

Subjects: *CLICK chemistry; *CHITINASE; *RING formation (Chemistry)

• Source: Proceedings of the National Academy of Sciences of the United States of America. 10/1/2013, Vol. 110 Issue 40, p15892-15897. 6p.

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Semibatch monomer addition as a general method to tune and enhance the mechanics of polymer networks via loop-defect control.

• Authors : Yuwei Gu; Ken Kawamoto; Mao Chen

Subjects: COLLOIDS; LOOPS (Group theory); POLYMER networks

• Source: Proceedings of the National Academy of Sciences of the United States of America; 5/9/2017, Vol. 114 Issue 19, p4875-4880, 6p, 1 Color Photograph, 1 Chart, 2 Graphs

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